Induction of resistance against the transplantation of leukemias induced by Rauscher virus.
نویسندگان
چکیده
A state of relative resistance against the transplantation of isografts of leukemias induced by the Rauscher virus (RV) was developed in HALB/*' an(l CDFi mice by pretreatment with X-irradiated tumor cells. In mice pretreated with cells from 1 tumor, significant cross-protection was obtained for all other RV-induced tumors tested and for some tumors induced by Moloney virus, but not for leukemia LI 210. Although marginal resistance was observed on a few occasions, the inoculation of infectious RV was not an efficient method of inducing trans plantation resistance in BALB/c and CDFi mice. In CDFi mice resistance to grafts of RV-induced tumors was accompanied by resistance to challenge with RV and the presence of circulating RV neutralizing antibodies.
منابع مشابه
Studies on Induced Resistance against Isotransplants of Virus-induced Leukemia.
The antigenicity of several well established Moloney virus-induced transplantable leukemias was studied. Resistance was developed by pretreatment of isologous mice with x-radiated tumor tissue. In general, the neoplasms grew more rapidly in preirradiated mice (400 r) than in normal mice, and at low inoculum concentrations a higher percentage of tumors was observed in the pre-irradiated animals....
متن کاملComparative studies on the induction of transplantation resistance in BALB-c and C57BL-6 mice in three murine leukemia systems.
Syngeneic X-irradiated Friend, Moloney, and Rauscher (FAIR) lymphomas readily induce transplantation resistance in C57BL/6 mice. Similar resistance is more difficult to induce in BALB/c mice. To determine whether this difference in response is due to a lesser immunogenicity of FMR cells of BALB/c ori gin, C57BL/6 mice were pretreated with viable or X-irradiated BALB/c FMR cells, or with X-irrad...
متن کامل[CANCER RESEARCH 32, 1671—1678,August 1972] SUMMARY CS7BL/6 mice were infected as neonates or as adults with Rauscher leukemia virus (RLV) and were challenged at various times thereafter with syngeneic Rauscher lymphoma
CS7BL/6 mice were infected as neonates or as adults with Rauscher leukemia virus (RLV) and were challenged at various times thereafter with syngeneic Rauscher lymphoma cells. In addition, sera obtained prior to challenge were tested by immunofluorescence against Rauscher lymphoma cells. Mice infected as adults with a 10' dilution of RLV exhibited strong transplantation resistance within 1 week ...
متن کاملCell-surface antigens induced by Friend and Rauscher virus complexes and their associated lymphatic leukemia viruses in the rat.
The WKA/Mk rat tumors induced by Friend virus complex, Rauscher virus complex, and their associated lymphatic leukemia viruses were investigated for their antigenic relationhips with transplantation experiments and cytotoxicity tests. It was found that Friend lymphatic leukemia virus-induced tumors lacked part of the tumor-associated transplantation antigens (TATA's) on Friend virus complex-ind...
متن کاملCross-resistance to the transplantation of syngeneic Friend, Moloney, and Rauscher virus-induced tumors.
Immimofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation stu...
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عنوان ژورنال:
- Cancer research
دوره 26 8 شماره
صفحات -
تاریخ انتشار 1966